Dengue Virus Antigens
Dengue fever virus, abbreviated as DENV, belongs to the Flaviviridae family of the genus Flavivirus. DENV transmitted primarily by mosquitoes often causes mosquito-borne tropical diseases. The DENV-infected host has a symptom, such as high fever, vomiting, headache, muscle and joint pain, and a characteristic skin rash, which usually begins three to fourteen days after infection.
People often take two to seven days to recover from illnesses associated with DENV, but in some cases, people infected with DENV can develop life-threatening dengue hemorrhagic fever, resulting in bleeding, levels of low blood platelets and loss of blood plasma, or dengue shock syndrome, where dangerously low blood pressure occurs. Figure 1 shows the outer surface of the entire dengue fever virus:
Dengue fever virus is an RNA virus homogeneous to West Nile virus, Japanese encephalitis virus, and yellow fever virus. The dengue virus genome contains approximately 11,000 nucleotide bases, encoding three different types of protein molecules (C, prM, and E) that make up the virus particle and seven other types of protein molecules (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5) that are found only in infected host cells and are necessary for the life cycle of the virus.
There are five serotypes of the dengue fever virus, of which the first four are called DENV-1, DENV-2, DENV-3, and DENV-4. In 2013, another type was found, the fifth type. Among those five serotypes, their antigenicity differs from each other even though they have a similar symptom after the hosts become infected with them. Figure 2 shows the internal structure of the dengue fever virus:
Dengue fever is a mosquito-borne viral disease in many tropical and subtropical parts of the world. An estimated 390 million dengue infections occur worldwide each year and around 96 million results in disease. Many scientists are working to develop vaccines that can prevent the dengue virus.
Now Creative Diagnostics can provide DENV antigens, antibodies, and ELISA kits to help investigators perform the preliminary evaluation. Our PhD-level scientists are always ready to help you find the most suitable reagents.